| # | Metro | Startups | Population | Per 100,000 Residents |
|---|---|---|---|---|
| 1 | Pittsburgh | 295 | 2,439,940 | 12.09 |
| 2 | Portland — the Silicon Forest | 265 | 2,520,987 | 10.51 |
| 3 | Gettysburg | 10 | 106,115 | 9.42 |
| 4 | New England | 253 | 4,953,354 | 5.11 |
| 5 | Greater Charlotte | 19 | 430,330 | 4.42 |
| 6 | Boulder | 13 | 328,961 | 3.95 |
| 7 | Alaska | 28 | 735,706 | 3.81 |
| 8 | Green Bay -- Titletown | 12 | 331,145 | 3.62 |
| 9 | the DMV (DC, Maryland, Virginia) | 228 | 6,318,377 | 3.61 |
| 10 | Wyoming | 21 | 582,397 | 3.61 |
| 11 | Youngstown | 14 | 427,420 | 3.28 |
| 12 | Walla Walla | 2 | 62,161 | 3.22 |
| 13 | the Research Triangle | 71 | 2,336,314 | 3.04 |
| 14 | Ames | 3 | 100,466 | 2.99 |
| 15 | Bozeman & Greater Yellowstone | 15 | 537,230 | 2.79 |
| 16 | Greater Atlanta | 157 | 6,256,377 | 2.51 |
| 17 | Spokane | 14 | 597,123 | 2.34 |
| 18 | Nebraska | 45 | 1,978,707 | 2.27 |
| 19 | Kansas City | 49 | 2,218,142 | 2.21 |
| 20 | the Sun Belt — Arizona | 156 | 7,378,838 | 2.11 |
| 21 | North Dakota | 15 | 784,841 | 1.91 |
| 22 | Cincinnati | 43 | 2,262,262 | 1.90 |
| 23 | Des Moines | 13 | 693,166 | 1.88 |
| 24 | New Orleans | 18 | 981,662 | 1.83 |
| 25 | Silicon Valley | 162 | 9,107,604 | 1.78 |
| 26 | South Dakota | 15 | 907,428 | 1.65 |
| 27 | Indianapolis | 34 | 2,151,989 | 1.58 |
| 28 | New Mexico | 33 | 2,120,246 | 1.56 |
| 29 | Montana | 14 | 932,137 | 1.50 |
| 30 | Baton Rouge | 11 | 875,313 | 1.26 |
| 31 | Hawaii | 18 | 1,445,235 | 1.25 |
| 32 | Alabama | 63 | 5,086,768 | 1.24 |
| 33 | Harrisburg | 7 | 604,155 | 1.16 |
| 34 | Greater Columbus | 24 | 2,175,788 | 1.10 |
| 35 | Nevada | 33 | 3,184,612 | 1.04 |
| 36 | Utah (Silicon Slopes) | 35 | 3,392,331 | 1.03 |
| 37 | Greater Cleveland | 22 | 2,171,526 | 1.01 |
| 38 | West Virginia | 18 | 1,778,373 | 1.01 |
| 39 | Austin | 24 | 2,426,592 | 0.99 |
| 40 | New England (NH · VT · ME · RI · CT) | 80 | 8,156,100 | 0.98 |
| 41 | Richland | 3 | 311,807 | 0.96 |
| 42 | Idaho (Boise) | 18 | 1,934,262 | 0.93 |
| 43 | Greater St. Louis | 26 | 2,810,850 | 0.92 |
| 44 | Arkansas | 22 | 2,471,665 | 0.89 |
| 45 | Puerto Rico | 28 | 3,234,309 | 0.87 |
| 46 | the Twin Cities | 32 | 3,713,668 | 0.86 |
| 47 | Oklahoma | 34 | 4,028,634 | 0.84 |
| 48 | Denver | 25 | 3,002,721 | 0.83 |
| 49 | Upstate New York | 55 | 7,009,118 | 0.78 |
| 50 | Mississippi | 23 | 2,946,779 | 0.78 |
| 51 | Seattle | 29 | 4,061,920 | 0.71 |
| 52 | Detroit | 30 | 4,376,828 | 0.69 |
| 53 | Northwest Arkansas | 4 | 577,726 | 0.69 |
| 54 | Kentucky | 28 | 4,081,359 | 0.69 |
| 55 | Milwaukee | 9 | 1,568,938 | 0.57 |
| 56 | Greater Orlando | 14 | 2,793,746 | 0.50 |
| 57 | Dallas | 26 | 5,382,430 | 0.48 |
| 58 | South Carolina | 23 | 4,865,895 | 0.47 |
| 59 | California | 51 | 11,281,795 | 0.45 |
| 60 | New York City | 88 | 19,798,537 | 0.44 |
| 61 | the Cedar Rapids-Iowa City Corridor | 2 | 455,824 | 0.44 |
| 62 | Tampa Bay | 14 | 3,304,691 | 0.42 |
| 63 | Houston | 29 | 7,442,788 | 0.39 |
| 64 | Philadelphia | 24 | 6,272,014 | 0.38 |
| 65 | Pennsylvania | 17 | 4,456,245 | 0.38 |
| 66 | Erie, PA | 1 | 269,052 | 0.37 |
| 67 | Greater San Diego | 12 | 3,288,774 | 0.36 |
| 68 | Greater San Antonio | 9 | 2,662,733 | 0.34 |
| 69 | Greater Los Angeles | 38 | 12,974,487 | 0.29 |
| 70 | Monterey | 1 | 437,613 | 0.23 |
| 71 | Lehigh Valley (Allentown-Bethlehem-Easton) | 2 | 873,603 | 0.23 |
| 72 | Iowa | 7 | 3,210,507 | 0.22 |
| 73 | Washington State | 5 | 2,253,744 | 0.22 |
| 74 | Greater Miami / South Florida | 12 | 6,249,291 | 0.19 |
| 75 | Greater Chicago | 16 | 9,371,595 | 0.17 |
| 76 | Colorado | 3 | 1,812,743 | 0.17 |
| 77 | Texas | 16 | 9,670,721 | 0.17 |
| 78 | Georgia | 7 | 4,383,151 | 0.16 |
| 79 | Fort Worth | 3 | 2,603,160 | 0.12 |
| 80 | Michigan | 6 | 5,331,111 | 0.11 |
| 81 | Nashville | 2 | 2,079,596 | 0.10 |
| 82 | Tennessee | 5 | 4,986,787 | 0.10 |
| 83 | Minnesota | 2 | 1,999,896 | 0.10 |
| 84 | Florida | 8 | 10,068,349 | 0.08 |
| 85 | Hampton Roads | 1 | 1,787,235 | 0.06 |
| 86 | Oregon | 2 | 4,109,526 | 0.05 |
| 87 | Missouri | 1 | 2,755,527 | 0.04 |
| 88 | Ohio | 2 | 4,707,274 | 0.04 |
| 89 | Illinois | 1 | 2,861,906 | 0.03 |
| 90 | Piedmont Triad (Greensboro-Winston-Salem-High Point) | 0 | 1,724,503 | 0.00 |
| 91 | North Carolina | 0 | 6,669,587 | 0.00 |
| 92 | State College, PA | 0 | 158,576 | 0.00 |
| 93 | Madison, WI | 0 | 572,674 | 0.00 |
| 94 | Louisiana | 0 | 2,754,986 | 0.00 |
| 95 | Wisconsin | 0 | 3,376,106 | 0.00 |