| # | Metro | Startups | Population | Per 100,000 Residents |
|---|---|---|---|---|
| 1 | Pittsburgh | 295 | 2,443,921 | 12.07 |
| 2 | Portland — the Silicon Forest | 266 | 2,510,529 | 10.60 |
| 3 | Gettysburg | 10 | 105,183 | 9.51 |
| 4 | New England | 254 | 4,917,661 | 5.17 |
| 5 | Greater Charlotte | 21 | 421,641 | 4.98 |
| 6 | Boulder | 13 | 328,317 | 3.96 |
| 7 | Alaska | 28 | 733,971 | 3.81 |
| 8 | the DMV (DC, Maryland, Virginia) | 228 | 6,263,796 | 3.64 |
| 9 | Green Bay -- Titletown | 12 | 329,375 | 3.64 |
| 10 | Wyoming | 21 | 579,761 | 3.62 |
| 11 | Youngstown | 14 | 428,430 | 3.27 |
| 12 | Walla Walla | 2 | 62,102 | 3.22 |
| 13 | the Research Triangle | 71 | 2,287,314 | 3.10 |
| 14 | Ames | 3 | 98,592 | 3.04 |
| 15 | Bozeman & Greater Yellowstone | 15 | 529,288 | 2.83 |
| 16 | Greater Atlanta | 157 | 6,176,937 | 2.54 |
| 17 | Spokane | 14 | 591,793 | 2.37 |
| 18 | Nebraska | 45 | 1,965,926 | 2.29 |
| 19 | Kansas City | 49 | 2,202,006 | 2.23 |
| 20 | the Sun Belt — Arizona | 157 | 7,268,175 | 2.16 |
| 21 | North Dakota | 15 | 779,361 | 1.92 |
| 22 | Cincinnati | 43 | 2,246,830 | 1.91 |
| 23 | Des Moines | 13 | 682,467 | 1.90 |
| 24 | Silicon Valley | 166 | 9,101,124 | 1.82 |
| 25 | New Orleans | 18 | 988,763 | 1.82 |
| 26 | South Dakota | 15 | 899,194 | 1.67 |
| 27 | Indianapolis | 34 | 2,128,089 | 1.60 |
| 28 | New Mexico | 33 | 2,114,768 | 1.56 |
| 29 | Montana | 14 | 923,187 | 1.52 |
| 30 | Alabama | 64 | 5,054,253 | 1.27 |
| 31 | Baton Rouge | 11 | 871,379 | 1.26 |
| 32 | Hawaii | 18 | 1,445,635 | 1.25 |
| 33 | Harrisburg | 7 | 597,894 | 1.17 |
| 34 | Greater Columbus | 25 | 2,151,847 | 1.16 |
| 35 | Utah (Silicon Slopes) | 35 | 3,331,187 | 1.05 |
| 36 | Nevada | 33 | 3,141,000 | 1.05 |
| 37 | Austin | 24 | 2,357,497 | 1.02 |
| 38 | Greater Cleveland | 22 | 2,171,978 | 1.01 |
| 39 | West Virginia | 18 | 1,784,462 | 1.01 |
| 40 | New England (NH · VT · ME · RI · CT) | 80 | 8,104,207 | 0.99 |
| 41 | Richland | 3 | 307,900 | 0.97 |
| 42 | Idaho (Boise) | 18 | 1,893,296 | 0.95 |
| 43 | Greater St. Louis | 26 | 2,809,414 | 0.93 |
| 44 | Arkansas | 22 | 2,469,215 | 0.89 |
| 45 | Oklahoma | 35 | 3,995,260 | 0.88 |
| 46 | the Twin Cities | 32 | 3,693,351 | 0.87 |
| 47 | Puerto Rico | 28 | 3,254,885 | 0.86 |
| 48 | Denver | 25 | 2,977,085 | 0.84 |
| 49 | Upstate New York | 57 | 7,008,487 | 0.81 |
| 50 | Mississippi | 23 | 2,951,438 | 0.78 |
| 51 | Detroit | 32 | 4,367,620 | 0.73 |
| 52 | Seattle | 29 | 4,021,467 | 0.72 |
| 53 | Northwest Arkansas | 4 | 563,436 | 0.71 |
| 54 | Kentucky | 28 | 4,061,369 | 0.69 |
| 55 | Milwaukee | 9 | 1,566,361 | 0.57 |
| 56 | Greater Orlando | 14 | 2,721,022 | 0.51 |
| 57 | Dallas | 26 | 5,252,554 | 0.49 |
| 58 | South Carolina | 23 | 4,791,133 | 0.48 |
| 59 | New York City | 92 | 19,756,722 | 0.47 |
| 60 | California | 52 | 11,222,760 | 0.46 |
| 61 | the Cedar Rapids-Iowa City Corridor | 2 | 453,380 | 0.44 |
| 62 | Greater San Diego | 14 | 3,282,782 | 0.43 |
| 63 | Tampa Bay | 14 | 3,240,469 | 0.43 |
| 64 | Houston | 29 | 7,274,714 | 0.40 |
| 65 | Philadelphia | 24 | 6,241,882 | 0.38 |
| 66 | Pennsylvania | 17 | 4,448,668 | 0.38 |
| 67 | Erie, PA | 1 | 269,544 | 0.37 |
| 68 | Greater San Antonio | 9 | 2,612,802 | 0.34 |
| 69 | Greater Los Angeles | 39 | 13,012,469 | 0.30 |
| 70 | Washington State | 6 | 2,234,930 | 0.27 |
| 71 | Monterey | 1 | 435,834 | 0.23 |
| 72 | Lehigh Valley (Allentown-Bethlehem-Easton) | 2 | 866,764 | 0.23 |
| 73 | Iowa | 7 | 3,195,937 | 0.22 |
| 74 | Greater Miami / South Florida | 12 | 6,138,876 | 0.20 |
| 75 | Greater Chicago | 16 | 9,359,555 | 0.17 |
| 76 | Colorado | 3 | 1,801,100 | 0.17 |
| 77 | Texas | 16 | 9,587,775 | 0.17 |
| 78 | Georgia | 7 | 4,347,510 | 0.16 |
| 79 | Fort Worth | 3 | 2,555,001 | 0.12 |
| 80 | Michigan | 6 | 5,315,581 | 0.11 |
| 81 | Nashville | 2 | 2,043,713 | 0.10 |
| 82 | Tennessee | 5 | 4,942,369 | 0.10 |
| 83 | Minnesota | 2 | 1,994,110 | 0.10 |
| 84 | Florida | 8 | 9,828,514 | 0.08 |
| 85 | Hampton Roads | 1 | 1,782,590 | 0.06 |
| 86 | Oregon | 2 | 4,093,795 | 0.05 |
| 87 | Missouri | 1 | 2,743,854 | 0.04 |
| 88 | Ohio | 2 | 4,710,407 | 0.04 |
| 89 | Illinois | 1 | 2,871,607 | 0.03 |
| 90 | Piedmont Triad (Greensboro-Winston-Salem-High Point) | 0 | 1,709,224 | 0.00 |
| 91 | North Carolina | 0 | 6,587,802 | 0.00 |
| 92 | State College, PA | 0 | 158,041 | 0.00 |
| 93 | Madison, WI | 0 | 564,777 | 0.00 |
| 94 | Louisiana | 0 | 2,760,883 | 0.00 |
| 95 | Wisconsin | 0 | 3,365,751 | 0.00 |